New PDF release: Anabolic Steroids

By H.-L. Krüskemper (Auth.)

ISBN-10: 1483231267

ISBN-13: 9781483231266

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2. 3. 4. 5. 6. 7. 8. 9. 10. 11. 12. 13. 14. 15. {\\ 65)]. Of all the anabolic steroids, only 1 -methyl- 17/3-hydroxy-5a: androst-1 -en-3-one (methenolone), 17a-methyl-17/3-hydroxyandrosta-l,4-dien-3-one (methandrostenolone), a n d the 19-norsteroids already discussed h a v e been tested for the possibility of aromatization. T h e investigations of R y a n (185) suggest that 17/3h y d r o x y a n d r o s t a - l , 4 - d i e n - 3 - o n e is aromatized to a m e a s u r a b l e extent by the placental e n z y m e system (cf.

N i t r o g e n retention could not b e raised appreciably by an increased d o s e of the extract. T h e last injection w a s followed by greater nitrogen excretion resulting in a negative nitrogen balance. This presumably w a s a rebound p h e n o m e n o n . T h e difference in reaction of lean and fat dogs w a s pointed put. Shortly after that, Kochakian p r o v e d that the changes in nitrogen balance w e r e androgen-dependent. A n d r o s t 4-ene-3,l7-dione (259) and testosterone acetate (233) resembled the urine extracts in effecting a shift of the nitrogen balance to the positive side.

8, 1 9 8 - 2 0 3 ) with mice, rats, and guinea pigs, yielded the following important results with respect to the myotropic action of androgens and several anabolic steroids. 1. Castration of growing male rats and guinea pigs effects a gradual slowing d o w n of the increase in weight. In the rat, all skeletal muscles and the skin participate in this change in proportion (200), w h e r e a s , in the guinea pig, some muscles are affected m o r e strongly by this involution than others (8). 2. T h e involution of muscles after castration can be reversed by the administration of androgen (8,203); h o w e v e r , only very massive dosages of androgen are able to effect a gain in weight going beyond the normal (202).

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Anabolic Steroids by H.-L. Krüskemper (Auth.)

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