New PDF release: Annual Reports in Medicinal Chemistry, Vol. 35

By Annette M. Doherty, William K. Hagmann

ISBN-10: 0120405350

ISBN-13: 9780120405350

Annual studies in Medicinal Chemistry offers well timed and demanding studies of vital themes in medicinal chemistry including an emphasis on rising subject matters within the organic sciences that are anticipated to supply the foundation for completely new destiny remedies.

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Additional info for Annual Reports in Medicinal Chemistry, Vol. 35

Example text

Most of the over 40 known FAD PS defects are missense mutations, occurring in topologically diverse regions of the proposed 6-8 TMD (Figure 3) PS structure (44,80). A model suggesting the alignment of certain TMD FAD residues on the same faces of PS TMD Lumenal TMD 6 TMD 7 helices has been suggested (22,81). Presenilin holoproteins are subject to a proteolytic cleavage in the cytoplasmic loop bridging putative TMD's Cytoso 6 and 7, which generates N- (30 kDa) erm and C-terminal (20 kDa) fragments.

Fuller, S. Edenson, J. A. L. Biere, E. Curran, T. -C. Louis, F. Collins, J. Treanor, G. Rogers and M. Citron, Science, 286, 735 (1999). R. J. E. Shuck, H. C. M. R. C. R. E. B. G. A. L. E. Gurney, Nature, 402, 533 (1999). Chap. 4 55. 56. 57. 58. 59. 60. 61. 62. 63. 64. 65. 66. 67. 68. 69. 70. 71. 72. 73. 74. 75. 76. 77. 78. 79. 80. 81. 82. 83. 84. 85. 86. 87. Secretase Inhibitor8 O18on, Thompson 3__99 X. Lin, G. Koelsch, S. Wu, D. Downs, A. Dashti and J. Tang, Proc. Natl. Acad. Sci. U. S. , 97, 1456 (2000).

Dashti and J. Tang, Proc. Natl. Acad. Sci. U. S. , 97, 1456 (2000). S. P. Anderson, R. S. Basi, R. Caccavello, D. Davis, M. F. Dovey, N. Frigon, J. Hong, K. Jacobson-Croak, N. Jewett, P. Keim, J. Knops, I. Lieberburg, M. Power, H. Tan, G. Tatsuno, J. Tung, D. Schenk, P. M. Suomensaari, S. Wang, D. Walker, J. Zhao, L. McConlogue and V. John, Nature, 402, 537 (1999). G. S. C. Sung, S. L. Kolson, T. Y. W. Doms, Nat. , 3, 1021 (1997). J. Knops, S. Suomensaari, M. Lee, L. McConlogue, P. Seubert and S.

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Annual Reports in Medicinal Chemistry, Vol. 35 by Annette M. Doherty, William K. Hagmann

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