Read e-book online Annual Reports in Medicinal Chemistry, Vol. 39 PDF

By Annette M. Doherty

ISBN-10: 0120405393

ISBN-13: 9780120405398

Annual experiences in Medicinal Chemistry keeps to target supplying well timed and demanding experiences of significant issues in medicinal chemistry including an emphasis on rising issues within the organic sciences, that are anticipated to supply the root for completely new destiny cures. Sections I-IV are illness oriented and usually document on particular medicinal brokers. Sections V and VI proceed to stress vital subject matters in medicinal chemistry, biology, and drug layout. * Annual finished reports of the previous yr literature in lots of subject matters of curiosity to medicinal chemists * incorporates a finished set of indices to simply find themes in Volumes 1-38 of this sequence * presents severe evaluate on sizzling themes in medicinal chemistry

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Millan, A. Gobert, F. Lejeune, A. Dekeyne, A. Newman-Tancredi, V. -M. Rivet and D. Cussac, J. Pharmacol. Exp. , 2003, 306, 954. [68] A. Chagraoui, P. Protais, T. Filloux and E. Mocaer, Psychopharmacology, 2003, 170, 17. [69] C. Pegurier, L. Morellato, E. Chahed, J. Andrieux, J. P. Nicolas, J. A. Boutin, C. Bennejean, P. Delagrange, M. Langlois and M. Mathe-Allainmat, Bioorg. Med. , 2003, 11, 789. [70] C. Descamps-Francois, S. Yous, P. Chavatte, V. Audinot, A. Bonnaud, J. A. Boutin, P. Delagrange, C.

A leading entry was MK-0767 8 (Merck, Phase III) until its suspension from development due to the formation of a rare hepatic tumor during long term safety studies. Tesaglitazar 9 (Astra Zeneca) is in Phase III clinical development, and three other candidates with dual PPAR-a and g co-activators are in Phase II clinical development [6]. 2. Retinoid X receptor (RXR) modulators RXR is a nuclear receptor that plays a critical role in the activation of many genes by formation of functional heterodimers with other nuclear hormone receptors including the PPARs and LXR in the presence of small molecule ligands.

Reiter, J. , 2004, 36, 1. M. Mor, C. Silva, F. Vacondio, P. V. Plazzi, S. Bertoni, G. Spadoni, G. Diamantini, A. Bedini, G. Tarzia, M. Zusso, D. Franceschini and P. Giusti, J. , 2004, 36, 95. R. Hardeland, A. Coto-Montes and B. Poeggeler, Chronobiol. , 2003, 20, 921. P. Barrett, S. Conway and P. J. Morgan, J. , 2003, 35, 221. M. L. Dubocovich, M. A. Rivera-Bermude, M. J. Gerdin and M. I. , 2003, 8d, 1093. C. Liu, D. R. Weaver, X. Jin, L. P. Shearman, R. L. Pieschl, V. K. Gribkoff and S. M. Reppert, Neuron, 1997, 19, 91.

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Annual Reports in Medicinal Chemistry, Vol. 39 by Annette M. Doherty

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