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By G. H. Bourne

ISBN-10: 0123643767

ISBN-13: 9780123643766

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R. (1977). J. Biol. Chem. 252, 2787. , and Davis, P. (1977). Biochem. Biophys. Res. Commun. 78, 697. , and Schoenl, M. (1977). Clin. Res. 25, 305a. , and Frieden, E. (1975). Endocrinology 97, 1019. , and Shioya, N. (1977). Mol. Cell. Endocrinol. 7, 89. INTERNATIONAL REVIEW OF CYTOLOGY, SUPPLEMENT 15 The Partitioning of Cytoplasmic Organelles at Cell Division C. WILLIAM BIRKY, JR. Department of Genetics and Interdepartmental Program in Molecular, Cellular, Developmental Biology, The Ohio State University, Columbus, Ohio I.

A. 74, 1816. Martial, J. , Seeburg, P. , Goodman, H. , and Baxter, J. D. (1977b). Proc. Nati. Acad. Sci. A. 74, 4293. REGULATION OF GENETIC ACTIVITY 47 Meyer, W. , Migeon, B. , and Migeon, G. J. (1975). Proc. Nati. Acad. Sci. A. 72, 1469. , Morris, S. , and Cohen, P. P. (1979). Proc. Nati. Acad. Sci. A. 76, 3179. , and Ingram, V. M. (1965). Proc. Nati. Acad. Sci. A. 54, 967. Nadsen, S. , and Sonne, O. (1978). Nature (London) 262, 793. , and Imura, H. (1979). Biochem. J. 182, 377. , Smith, J. , and Goodman, H.

Major Working Hypotheses on the Mechanisms of Genetic Activity Regulation by Thyroid Hormones In 1974 Baxter et al. suggested a model for the interaction of thyroid hormones, mainly of triiodothyronine, with the genetic apparatus of hormone-sensitive cells (Fig. 1). Following this model, T 3 rather than T 4 is responsible for the genetic effect of thyroid hormones. Free T 3 penetrates the nucleus, binds to the chromatin-specific receptor, and induces mRNA synthesis. Features of the hyCYTOPLASM FIG.

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