Download e-book for iPad: Biotransformations in Organic Chemistry: A Textbook by Kurt Faber

By Kurt Faber

ISBN-10: 3642173926

ISBN-13: 9783642173929

ISBN-10: 3642173934

ISBN-13: 9783642173936

The use of biocatalysts, hired both as remoted enzymes or entire microbial cells, deals a outstanding arsenal of hugely selective ameliorations for state of the art man made natural chemistry. during the last 20 years, this system has turn into an fundamental device for uneven synthesis, not just on the educational point, but additionally on an business scale.

This well-established textbook on biocatalysis presents a foundation for undergraduate and graduate classes in smooth natural chemistry, in addition to a condensed advent into this box. After a simple advent into using biocatalysts—principles of stereoselective changes, enzyme homes and kinetics—the types of reactions are defined in keeping with the 'reaction principle', reminiscent of hydrolysis, aid, oxidation, C–C bond formation, and so on. targeted concepts, comparable to using enzymes in natural solvents, immobilization strategies and converted or synthetic enzymes, are taken care of in a separate part. a last bankruptcy offers with thebasic ideas for the secure and sensible dealing with of biocatalysts.

In this thoroughly revised sixth version, emphasis has been given to a stronger didactic type together with coloured portraits with a purpose to facilitate a deeper knowing of the underlying rules. New advancements, reminiscent of transamination, enzyme promiscuity and functions on business scale in the box of 'white biotechnology' are included.

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Rev. Drug Discov. 1: 753 74. Sheldon RA (1993) Chirotechnology. Marcel Dekker, New York 75. Collins AN, Sheldrake GN, Crosby J (eds) (1992, 1997) Chirality in Industry, 2 vols. Wiley, Chichester 76. Morrison JD (ed) (1985) Chiral catalysis. In: Asymmetric Synthesis, vol 5. Academic Press, London 77. Hanessian S (1983) Total Synthesis of Natural Products: the ‘Chiron’ Approach. Pergamon Press, Oxford 78. Scott JW (1984) Readily available chiral carbon fragments and their use in synthesis. In: Morrison JD, Scott JW (eds) Asymmetric Synthesis.

Ed. 47: 8782 81. Phillips RS (1996) Trends Biotechnol. 14: 13 82. Schuster M, Aaviksaar A, Jakubke HD (1990) Tetrahedron 46: 8093 83. Yeh Y, Feeney (1996) Chem. Rev. 96: 601 84. Klibanov AM (1990) Acc. Chem. Res. 23: 114 85. D’Arrigo P, Fuganti C, Pedrocchi-Fantoni G, Servi S (1998) Tetrahedron 54: 15017 86. Anfinsen CB (1973) Science 181: 223 30 87. 88. 89. 90. 91. 92. 93. 94. 95. 96. 97. 98. 99. 100. 101. 102. 103. 104. 105. 106. 107. 108. 109. 110. 111. 112. 113. 114. 115. 116. 117. 118. 119.

6) compete for the active site of the enzyme. Due to the chiral environment of the active site of the enzyme, diastereomeric enzyme-substrate complexes [EnzA] and [EnzB] are formed, which possess different values of free energy (DG) for their respective transition states [EnzA]6¼ and [EnzB]6¼. The result is a difference in activation energy (DDG6¼) for both of the enantiomeric substrates or the ‘enantiomeric orientations’, respectively. As a consequence, one enantiomer (or orientation) will be transformed faster than the other.

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Biotransformations in Organic Chemistry: A Textbook by Kurt Faber


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