By PD Dr. med. Ulrich F. Gruber (auth.)
The manifold difficulties of outrage are nonetheless of significant value, diagnostic and healing event of the "severely ailing" being provided with new info nearly each month. within the five periodicals that have came across their option to my table prior to now few days there are not any under 10 fascinating articles on questions referring to surprise examine [see Bibliography forty-one b, fifty three a, 60 a, 192 a, 242 a, 350 b, 810 a, 941 a, 1069 a, 1082 a]. the main pressing aspect nonetheless is to take care of as entire as attainable the target catalog of many of the surprise manifestations present in guy and in animals - but whilst to view interpretations of those phenomena of their relative and temporal "truth". difficulties of concern examine aren't purely attention-grabbing for his or her clinical worth but in addition for his or her medical implication. particularly, nearly each practising doctor is dealing with difficulties of blood substitute very widespread ly. The powerful or circulating blood quantity continues to be an enormous theoret ical and healing challenge within the surprise box. For years, U. F. GRUBER has pursued this query clinically and experimentally. This quantity offers with the area literature in a very thorough demeanour. This publication is made greater than a compilation by way of together with a protracted checklist of unique paintings performed with F. D. MOORE in Boston, within the Surgical division in Chur, with 1. E. GELIN and S. E.
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In taking these points into consideration one must assume that transfusion hepatitis occurs more frequently than many of the statistics listed would tend to indicate. More recent articles generally show higher figures. Overall Incidence of Transfusion Hepatitis. New extremely careful and complete follow-up studies with repeated transaminase determination and liver biopsies show the following figures for the frequency of post-transfusion hepatitis (icteric plus non-icteric cases): CREUTZFELDT et al.
The good therapeutic effect in the treatment of hypovolemic shock conditions with pooled plasma, dried plasma, PPS II and albumin have been documented experimentally [42,244,405,578,703,769,1048,1115,1155, 1245,1470,1472; see also 1214] and clinically [78, 114,260,306,705,710, 1509]. WARREN et al.  have shown the effectivity of the albumin therapy by means of careful circulatory analysis.
BLISS [165, 166, 167, 168], FREEDMAN , and HUTCHISON et al. [759,760] showed that deep-frozen homologous plasma leaves the vascular 3 Gruber, Blood Replacement Various Methods of Volume Replacement 34 system within 1 hour following infusion in normovolemic dogs and humans. Urticarial phenomena occur in half of the cases. We decided in 1964 to investigate this problem in hypovolemic humans [609, 612, 615]. For these experiments 1-2 weeks old citrated plasma was used, as is customary in Sweden for plasma transfusions and as it exactly corresponds to the portion of plasma in preserved blood.
Blood Replacement by PD Dr. med. Ulrich F. Gruber (auth.)