By Johan N.M. Heersche and J. A. Kanis (Eds.)
The purpose in placing jointly this seventh quantity of the Bone and Mineral study sequence has been to give top of the range, updated studies and in-depth analyses in components the place advancements are, or possibly will be, of significant curiosity to the Bone and Mineral learn neighborhood. The excessive regular already validated within the prior six volumes of this sequence (under course of Dr. William A. Peck) has been maintained. There has een a few incredible development made inside of a few components of bone and mineral study, while in different parts a gradual and sluggish accumulation of data has ended in elevated perception, in order good as together with stories in either components, the chapters emphasize the improvement of recent innovations. The bankruptcy matters coated are as follows
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Extra info for Bone and Mineral Research. A Regular Survey of Developments in the Field of Bone and Mineral Metabolism
Bone gla-protein: Price and Williamson, 1981). (b) Clustering: Numerous experimental results and theoretical considerations have led to revise the classical concept describing the s>/S> system as formed by only one solu tion and one solid phase. e. the existence of ordered chemical species belong ing to solution phase (clustering). There is increasing experimental evidence for a cer tain continuum between the fully ordered solid state and the fully disordered solute ion phase. A self-sustained mechanism for futher clustering in solution has been pro posed, based on the increased probability of clusters coming into contact and then coalescing (Larson and Garside, 1986).
1948a), but there is still no evidence that osteoclast precursors possess receptors for P T H . , 1988). T h e reported ef fects of P T H on bone formation in vivo and in vitro are contradictory; these paradoxical effects appear to be dose- and time-dependent. , 1982; Gunness and Hock, 1984). , 1984) in vitro. But alkaline phosphatase, a classical marker for the osteoblast phenotype, may be either inhibited (Majeska and R o d a n , 1982) or stimulated (Puzas and Brand, 1985) by P T H . The acute effects of P T H may represent its action on the pre-existing population of osteoblasts, whereas the intermittent and long-term effects result from changes in the population of cells belonging to osteoblastic cell line (osteoprogenitor-preosteoblastlining cell-osteocyte) and the de-differentiating effect of P T H on the osteoblasts.
G. minor changes in the physical properties of plasma membrane (which are also highly depen dent on calcium concentration (Düzgünes and Papahadjopoulos, 1983)), lead to large variations in cytosolic Car + concentration (excitability properties), while only small displacements of amounts of calcium mass are involved. 2). 1 - 0 . e. the interface with the extracellular fluids, with its poor permeability to calcium. Calcium enters the cell through the plasma membrane passively, down its electrochemical potential via either nonspecific leak or specific Ca 2 + channels.
Bone and Mineral Research. A Regular Survey of Developments in the Field of Bone and Mineral Metabolism by Johan N.M. Heersche and J. A. Kanis (Eds.)