Download e-book for iPad: C-H Bond Activation in Organic Synthesis by Jie Jack Li

By Jie Jack Li

ISBN-10: 148223310X

ISBN-13: 9781482233100

C–H activation includes any of quite a lot of suggestions, usually utilizing catalysts during which a carbon to hydrogen covalent bond of an natural compound is cleaved to switch the hydrogen with a sensible staff. C–H Activation for functionalization is the cutting-edge in natural chemistry. It permits chemists to hold out reactions within the such a lot environmentally pleasant style with the least illness of by-products. Written via an writer skilled during this speedily constructing the sector, this publication covers C–H activation via various catalysts.

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Ruthenium-Catalyzed Direct Arylations Through C―H Bond Cleavages. , Eds. Springer: Berlin, Heidelberg: 2010; Vol. 292, pp 211–229. ; Inoue, Y. Ortho-selective allylation of 2-pyridylarenes with allyl ­acetates catalyzed by ruthenium complexes. Organometallics 2006, 25, 4773–4778. ; Uemura, S. Organometallics 2004, 23, 5841–5848. 123. Foley, N. ; Lee, J. ; Gunnoe, T. ; Cundari, T. ; Petersen, J. L. J. Am. Chem. Soc. 2007, 129, 6765–6781. 124. ; Yi, C. S. Science 2011, 333, 1613–1616. 125. ; Hofmann, N.

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These iodine centered radicals abstract a hydrogen atom from a labile benzylic C―H bond to yield a resonance-stabilized benzylic radical. At this point in the mechanism, researchers seem divided on the next step. Some propose a second single electron transfer (SET) to form a benzylic carbocation,30 which undergoes ionic reactions to form product. Others suggest radical combination to form an alkyl halide or organic peroxide which reacts further under the reaction conditions to form product. The Fan group31 and Nicholas group32 independently propose the radical mechanism in the amination reaction they developed.

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C-H Bond Activation in Organic Synthesis by Jie Jack Li

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