By Hirohiko Tsujii (auth.), Hirohiko Tsujii, Tadashi Kamada, Toshiyuki Shirai, Koji Noda, Hiroshi Tsuji, Kumiko Karasawa (eds.)
This booklet serves as a pragmatic consultant for using carbon ions in melanoma radiotherapy. at the foundation of scientific event with greater than 7,000 sufferers with a variety of kinds of tumors taken care of over a interval of approximately two decades on the nationwide Institute of Radiological Sciences, step by step strategies and technological improvement of this modality are highlighted. The publication is split into sections, the 1st overlaying the underlying rules of physics and biology, and the second one part is a scientific overview through tumor website, focusing on the position of healing concepts and the pitfalls in therapy making plans. Readers will examine of the very best results bought with carbon-ion treatment for numerous forms of tumors when it comes to neighborhood regulate and toxicities. it truly is necessary to remember the fact that the carbon-ion beam is sort of a two-edged sword: until it truly is used competently, it could actually raise the chance of serious damage to serious organs. In early sequence of dose-escalation experiences, a few sufferers skilled severe antagonistic results resembling epidermis ulcers, pneumonitis, intestinal ulcers, and bone necrosis, for which salvage surgical procedure or hospitalization used to be required. To avert such hazardous effects, the adequacy of healing concepts and dose fractionations was once conscientiously tested in every one case. during this means, major advancements in therapy effects were accomplished and significant toxicities are not any longer saw. With that wisdom, specialists in suitable fields extend upon thoughts for therapy supply at every one anatomical web site, protecting symptoms and optimum remedy making plans. With its useful concentration, this publication will profit radiation oncologists, scientific physicists, scientific dosimetrists, radiation therapists, and senior nurses whose paintings includes radiation remedy, in addition to clinical oncologists and others who're attracted to radiation therapy.
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Additional resources for Carbon-Ion Radiotherapy: Principles, Practices, and Treatment Planning
These cells may still retain ability to synthesize DNA and proteins. These cells, however, have various functional aberrations; for example, the nucleus divides but fail in cytokinesis (the last stage of cell division following the nuclear division, division of cytoplasm) and the cell grows but cannot divide or shows abnormal morphology. In radiobiological observations after irradiation, which aim at counting the reproductive cell deaths, a colony consisting of 50 or more cells (after 5 to 6 divisions) is regarded as a colony originating from a surviving cell.
Damaged cells with SLD surviving the first irradiation can recover to become exactly like they were as original normal cells with no damage, when they have sufficient time to repair the damage to themselves before the second irradiation. Cells undergoing fractionated irradiation twice with a certain dose show a higher survival rate than those undergoing sequential irradiation with the same dose. A survival curve for the second irradiation after sufficient time has passed is similar to that for the first irradiation from dose zero.
In contrast to conventional photon therapy, this cannot be achieved by applying a uniform distribution of absorbed dose within the target volume due to the drastic change in the biological effectiveness of ion beam as shown in the previous section. In this section, biophysical models used in carbon-ion radiotherapy (C-ion RT) at HIMAC are explained. 1, the term relative biological effectiveness (RBE) is defined as a concept in radiobiology as the ratio of absorbed dose required to evoke the same biological effect (endpoint) by two different radiations.
Carbon-Ion Radiotherapy: Principles, Practices, and Treatment Planning by Hirohiko Tsujii (auth.), Hirohiko Tsujii, Tadashi Kamada, Toshiyuki Shirai, Koji Noda, Hiroshi Tsuji, Kumiko Karasawa (eds.)